Andrea DeBarber, PhD
Adjunct Faculty, NCNM
Research Assistant Professor, Physiology and Pharmacology Department
I obtained my PhD in chemistry in 1997 and subsequent Postdoctoral Fellowships at the NIH and OHSU further solidified my knowledge of synthetic and bioanalytical chemistry. In 2004 I was recruited to remain at OHSU as Associate Director of the Bioanalytical Shared Resource Facility. In this role my responsibilities include, in collaboration with OHSU clinicians and researchers, development of LC-mass spectrometry (LC-MS) methods for quantification of drugs and metabolite identification, as well as the analysis of endogenous steroids, sterols, lipids and thyroid hormone analogues. In 2008 I was appointed Director of a high resolution MS Facility at Portland State University. Although my training is as a basic scientist, due to my Bioanalytical Shared Resource Facility role, I had the opportunity to spend much of my time over the last 4-5 years on patient-oriented research projects. Working on problems more directly applicable to human health and disease has been energizing and I developed a strong interest in clinical research. NIH Training fellowships I was awarded in 2010 and 2011 allowed me to enroll in the OHSU Masters in Clinical Research Program and obtain advanced translational and clinical research training. As an analytical chemist with such training, I am able to successfully meet the challenge of integrating highly specialized and continuously evolving analytical methodology with biomedical research, and I am eager to devote my expertise, curiosity and time to this field. Foundation grants from the Friends of Doernbecher Foundation located in Portland, Oregon and the United Leukodystrophy Foundation located in DeKalb, Illinois have allowed me to begin developing an independent research program where the focus of my research has been using site-specific derivatization chemistries coupled with LC-MS/MS to provide improved diagnostic and newborn screening tests for rare genetic disorders of sterol and bile acid synthesis.